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| Auckland Tier IV Hard | Jan 9 2005 |
| 1 | Santangelo - Eleni Daniilidou(3) | 6-2 1-6 6-1 |
| 2 | Shahar Peer-Q - Santangelo | 6-3 4-6 6-2 |
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| Hobart Tier V Hard | Jan 16 2005 |
| 1 | Shinobu Asagoe(4) - Santangelo | 6-4 6-3 |
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| Australian Open Hard | Jan 30 2005 |
| 1 | Evie Dominikovic-WC - Santangelo | 6-75 6-4 6-3 |
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| Pattaya City Tier IV Hard | Feb 6 2005 |
| 1 | Santangelo - Kristina Brandi(5) | 6-1 6-2 |
| 2 | Evgenia Linetskaya - Santangelo | 3-6 6-2 6-2 |
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| Hyderabad Tier IV Hard | Feb 13 2005 |
| 1 | Santangelo - Jelena Dokic | 7-62 6-3 |
| 2 | Maria Kirilenko(8) - Santangelo | 3-6 6-3 7-64 |
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| Indian Wells Tier I Hard | Mar 20 2005 |
| 1 | Angela Haynes-WC - Santangelo | 6-4 6-4 |
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| Orange $50,000 Hard | Mar 20 2005 |
| Qual 1 | Santangelo - Sarah Fansler-WC | 6-4 6-1 |
| Qual 2 | Santangelo - Yulia Beygelzimer(8) | 6-4 6-2 |
| Qual 3 | Santangelo - Martina Muller | 6-2 4-6 6-1 |
| 1 | Santangelo-Q - Yuliana Fedak(7) | 6-4 6-3 |
| 2 | Galina Voskoboeva - Santangelo-Q | 6-4 7-65 |
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| Poza Rica $25,000 Hard | Apr 3 2005 |
| 1 | Santangelo(6) - Seda Noorlander-LL | 6-1 6-2 |
| 2 | Santangelo(6) - Olga Blahotova-Q | 6-1 6-4 |
| QF | Santangelo(6) - Nathalie Vierin(4) | 6-2 6-2 |
| SF | Santangelo(6) - Yvonne Meusburger(5) | 7-5 6-3 |
| F | Santangelo(6) - Ryoko Fuda-Q | 3-6 6-2 6-0 |
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| Coatzacoalcos $25,000 Hard | Apr 10 2005 |
| 1 | Santangelo(5) - Kildine Chevalier-Q | 6-4 6-3 |
| 2 | Santangelo(5) - Kyra Nagy | 6-2 6-2 |
| QF | Yvonne Meusburger(4) - Santangelo(5) | 4-6 7-5 6-4 |
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| Taranto $25,000 Clay | May 1 2005 |
| 1 | Santangelo(1) - Ekaterina Kosminskaya-Q | 6-3 6-0 |
| 2 | Santangelo(1) - Nikola Frankova-Q | 6-4 2-6 7-62 |
| QF | Santangelo(1) - Angelika Bachmann(8) | 6-0 6-74 6-0 |
| SF | Santangelo(1) - Ivana Abramovic(7) | 6-1 6-1 |
| F | Santangelo(1) - Kyra Nagy(3) | 6-1 6-0 |
| | |
| Rome Tier I Clay | May 15 2005 |
| Qual 1 | Santangelo - Selima Sfar(16) | 6-1 6-0 |
| Qual 2 | Santangelo - Ting Li (sr) | 6-4 4-6 6-4 |
| 1 | Santangelo-Q - Fabiola Zuluaga | 6-2 6-2 |
| 2 | Nadia Petrova(7) - Santangelo-Q | 6-3 6-1 |
| | |
| Roland Garros Clay | Jun 5 2005 |
| Qual 1 | Santangelo(20) - Aurelie Vedy | 6-3 1-6 6-1 |
| Qual 2 | Santangelo(20) - Sunitha Rao | 3-6 6-2 6-3 |
| Qual 3 | Santangelo(20) - Lenka Nemeckova | 6-1 6-3 |
| 1 | Sandra Kloesel-Q - Santangelo-Q | 7-65 6-1 |
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| Prostejov $75,000 Clay | Jun 5 2005 |
| 1 | Alena Vaskova - Santangelo(8) | 6-3 6-4 |
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| Wimbledon Grass | Jul 3 2005 |
| Qual 1 | Santangelo(14) - Eva Hrdinova | 6-2 3-6 6-2 |
| Qual 2 | Santangelo(14) - Sunitha Rao | walkover |
| Qual 3 | Santangelo(14) - Jana Kandarr | 6-3 6-3 |
| 1 | Santangelo-Q - Tatiana Poutchek-Q | 6-3 6-2 |
| 2 | Serena Williams(4) - Santangelo-Q | 4-6 6-3 6-2 |
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| Stockholm Tier IV Hard | Aug 14 2005 |
| 1 | Santangelo - Sandra Kleinova | 6-4 6-1 |
| 2 | Emilie Loit - Santangelo | 6-2 1-6 6-2 |
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| Bronx $50,000 Hard | Aug 21 2005 |
| 1 | Santangelo(4) - Sunitha Rao | 4-6 6-4 6-4 |
| 2 | Santangelo(4) - Vilmarie Castellvi | 6-3 6-4 |
| QF | Sybille Bammer(6) - Santangelo(4) | 6-3 7-67 |
| | |
| New Haven Tier II Hard | Aug 28 2005 |
| Qual 1 | Santangelo - Yuliana Fedak | 6-3 6-0 |
| Qual 2 | Jelena Kostanic(8) - Santangelo | 6-2 6-3 |
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| US Open Hard | Sep 11 2005 |
| 1 | Mary Pierce(12) - Santangelo | 6-2 6-4 |
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| Bordeaux $75,000 Clay | Sep 18 2005 |
| 1 | Lioudmila Skavronskaia - Santangelo(5) | 6-4 6-2 |
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| Tashkent Tier IV Hard | Oct 9 2005 |
| 1 | Tzipora Obziler - Santangelo(8) | 7-61 3-6 7-5 |
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| Joue les Tours $50,000 Hard | Oct 16 2005 |
| 1 | Santangelo(5) - Julia Babilon-Q | 6-4 6-0 |
| 2 | Santangelo(5) - Matea Mezak | 6-1 6-2 |
| QF | Santangelo(5) - Yulia Beygelzimer-Q | 7-64 6-4 |
| SF | Jelena Kostanic(1) - Santangelo(5) | 6-3 6-4 |
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| St. Raphael $50,000 Hard | Oct 23 2005 |
| 1 | Santangelo(5) - Galina Voskoboeva | 6-4 4-6 6-4 |
| 2 | Santangelo(5) - Elena Baltacha | 4-6 6-3 6-4 |
| QF | Santangelo(5) - Madalina Gojnea-Q | 6-0 7-63 |
| SF | Santangelo(5) - Virginie Pichet-Q | 6-4 6-2 |
| F | Maret Ani - Santangelo(5) | 6-3 7-5 |
| | |
| Hasselt Tier III Hard | Oct 30 2005 |
| 1 | Katarina Srebotnik(8) - Santangelo | 6-3 6-0 |
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| Poitiers $75,000 Hard | Nov 27 2005 |
| 1 | Emma Laine - Santangelo(5) | 6-2 6-1 |